Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Homo sapiens | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | Homo sapiens | - |
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P42336 | gene PI3KCA ; gene PI3KCA | - |
Homo sapiens | P42338 | gene PI3KCB; gene PI3KCB | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CAL-51 cell | - |
Homo sapiens | - |
HEK-293 cell | - |
Homo sapiens | - |
HEK-293FT cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
NIH-3T3 cell | - |
Homo sapiens | - |
SUM-1315MO2 cell | - |
Homo sapiens | - |
SUM-159PT cell | - |
Homo sapiens | - |
T-47D cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
class I PI3K | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | analysis of the mechanism by which phosphatidylinositol 4-phosphate 5-kinase Igammai2 and PI3K are integrated into a complex regulated by Src, resulting in the spatial generation of PIP2, which is the substrate PI3K required for PIP3 generation and subsequent Akt activation, the PIP2-generating enzyme controls Akt activation upstream of a PI3K enzyme | Homo sapiens |
physiological function | enzyme PI3K is rapidly recruited to activated growth factor receptors (SH2 domain of the adaptor subunit mediating the interaction to the phosphorylated YXXM motif of the receptor) or integrin-mediated adhesion complex (via interaction with focal adhesion kinase in the adhesion complex), promoting its activation and 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate synthesis. phosphatidylinositol 4-phosphate 5-kinase Igamma, EC 2.7.1.68, is the major PIPKI enzyme contributing to PI3K/Akt signaling in response to activation of growth factor and adhesion receptors in suspension condition, overview | Homo sapiens |